![]() ![]() Extensions to a procedure for generating locally identifiable reparameterisations of unidentifiable systems. 10.1016/s0025-5564(97)10004-9Įvans ND, Chappell MJ. Many algorithms for determining properties of (real) semi-algebraic sets rely upon the ability to compute smooth points. This combination of numerical algebraic geometry and differential algebra could be thought of as numerical differential algebra. A procedure for generating locally identifiable reparameterisations of unidentifiable non-linear systems by the similarity transformation approach. In the case where these input-output equations cannot be calculated using conventional differential algebra techniques, we also introduce a method to compute locally identifiable functions of parameters. 10.1016/j.mbs.2009.08.010īellman R, Astrom KJ. When the equations to be considered are defined over a subfield of the complex numbers, numerical methods can be used to perform algebraic geometric computations forming the area of numerical algebraic geometry. An algorithm for finding globally identifiable parameter combinations of nonlinear ODE models using Gröbner Bases. Meshkat N, Eisenberg M, DiStefano JJ III. While classical algebraic geometry has been studied for hundreds of years, numerical algebraic geometry has only recently been developed. Computers in Biology and Medicine 2007 88:52–61. Macaulay2 is a software system devoted to supporting research in algebraic geometry and commutative algebra, whose creation has been funded by the National Science Foundation since 1992. Numerically Solving Polynomial Systems with Bertini, Bates, Hauenstein, Sommese. DAISY: A new software tool to test global identifiability of biological and physical systems. Wampler on numerical computation of the geometric genus of curve. Several examples are used to demonstrate the new techniques.īellu G, Saccomani MP, Audoly S, D’Angiò L. For unidentifiable models, we present a novel numerical differential algebra technique aimed at computing a set of algebraically independent identifiable functions. For identifiable models, we present a novel approach to compute the identifiability degree. ![]() In this work, we use numerical algebraic geometry to determine if a model given by polynomial or rational ordinary differential equations is identifiable or unidentifiable. For unidentifiable models, a set of identifiable functions of the parameters are sought so that the model can be reparametrized in terms of these functions yielding an identifiable model. Unidentifiable models are models such that the unknown parameters can have an infinite number of values given input-output data. The total number of such values over the complex numbers is called the identifiability degree of the model. Identifiable models are models such that the unknown parameters can be determined to have a finite number of values given input-output data. A common problem when analyzing models, such as mathematical modeling of a biological process, is to determine if the unknown parameters of the model can be determined from given input-output data. ![]()
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